CORDIS Project
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This project investigates genetic interactions that lead to cell death in cancer cells with impaired DNA replication licensing. Focusing on colorectal cancer, it aims to identify overexpressed genes that contribute to the survival of these cells, using advanced techniques like CRISPR/Cas9 screening to discover potentia…
Genetic lethal interactions, which describe the lethal effect of combined perturbations in two or more genetic factors whilst individually have no effect, have emerged as a significant topic in the field of targeted cancer therapy.
Despite their promising performance in clinic, current genetic lethality-based therapies focus mainly on digenic interactions restricting the size recipient patients.
Complex genetic interactions that involve deregulation of innate mechanisms or cellular responses off…
PANEPISTIMIO PATRON
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
United Kingdom, SAFFRON WALDEN
Type: Research institute
Activity type: Research Organisations
SME: No
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