CORDIS Project
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This project aims to eliminate senescent cells from tissues to prevent their harmful effects, which can lead to inflammation and cancer progression. By understanding immune interactions and molecular pathways, the project seeks to develop strategies for targeting these cells, ultimately contributing to cancer preventio…
Cellular senescence, which is a terminal cell cycle arrest, is a potent tumor suppressor mechanism that limits cancer initiation and progression; it also limits tissue damage response.
While senescence is protective in the cell autonomous manner, senescent cells secrete a variety of factors that lead to inflammation, tissue destruction and promote tumorigenesis and metastasis in the sites of their presence.
Here we propose a unique approach – to eliminate senescent cells from tissues in order to…
WEIZMANN INSTITUTE OF SCIENCE
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