CORDIS Project
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This project explores the biology of bacterial L-forms, which lack a cell wall and are resistant to common antibiotics. It aims to understand their characteristics, potential clinical relevance, and interactions with mammalian systems, which may shed light on persistent infections and antibiotic resistance.
Despite the clear importance and multiple functions of the bacterial cell wall, many bacteria appearto be able to switch into a cell wall deficient or “L-form” state.
L-forms are very heterogeneous insize and shape and generally require osmotic stabilisers, such as 0.5 M sucrose, for viability.However, by lacking the requirement for a cell wall, L-forms are completely resistant to commoncell wall antibiotics, such as β-lactams, and they are probably protected from some elements ofinnate immune r…
UNIVERSITY OF NEWCASTLE UPON TYNE
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