CORDIS Project
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This research focuses on pre-mRNA splicing, a critical process in gene expression, particularly in understanding how chromatin influences splicing mechanisms. The project aims to uncover the role of the exon junction complex in splicing long introns, with implications for treating diseases linked to splicing errors.
Pre-mRNA splicing is an essential function in virtually all eukaryotic organisms.
In the human genome, 95% of the genes with multiple exons are subjected to alternative splicing, increasing the diversity of the transcriptome and ensuring the complexity of the organism.
Because of its prevalence in many physiological functions splicing mis-regulation has been linked to a large number of diseases, including various cancers.
In addition to providing diversity splicing presents an opportunity for ge…
INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH
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