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EICO-CODE investigates how eicosanoids, a type of bioactive lipid, influence CD8+ T cell responses in various organs. The project aims to uncover the mechanisms by which these tissue-derived factors shape T cell differentiation and function, ultimately enhancing immunity against cancer and viral infections.
CD8+ T cells are critical for immunity against infection and cancer.
Eliciting protective CD8+ T cell immunity is the main goal of many current and emerging immunotherapies aimed at treating these diseases, holding the promise to substantially improve patient outcomes.
Evidence suggests that T cell regulation by tissue-derived factors is one of the key mechanisms influencing the protective potential of CD8+ T cell responses, however, the nature and molecular impact of these factors remains incom…
EBERHARD KARLS UNIVERSITAET TUEBINGEN
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