CORDIS Project
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This project investigates genetic redundancy in E. coli by manipulating efflux pump genes to understand how overlapping functions influence evolutionary adaptation. It aims to reveal the long-term effects of redundancy on gene evolution and fitness through experimental evolution and comprehensive analysis.
In genetic redundancy, multiple genes in a genome perform the same or similar function.
Although redundancy is widespread across the tree of life, its evolutionary origins are not entirely understood.
Genetic redundancy may provide a fitness benefit during evolution by increasing gene dosage and protecting critical genes from deleterious mutations.
These fitness effects have been confirmed experimentally, but their long-term consequences for evolution have not been tested.
In this study, I will…
UNIVERSITAT ZURICH
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