CORDIS Project
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This project investigates how different pathways for internalizing the epidermal growth factor receptor (EGFR) influence its signaling and degradation. It focuses on the interactions between the plasma membrane, endoplasmic reticulum, and mitochondria, aiming to understand their role in cellular processes like migratio…
The integration of distinct internalization routes is crucial to determine the fate of plasma membrane (PM) receptors and the output of their signalling pathways.
Contact sites between cellular organelles adds a further layer of regulation by creating microdomains that favour different signalling and metabolic pathways.
These regulatory mechanisms are relevant to the epidermal growth factor receptor (EGFR).
We found that EGFR internalization through non-clathrin endocytosis (NCE) leads primarily…
UNIVERSITA DEGLI STUDI DI MILANO
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ISTITUTO EUROPEO DI ONCOLOGIA SRL
Italy, Milano
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
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