CORDIS Project
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The project aims to develop a new platform for gene therapy using tyrosine recombinases, which can integrate large DNA segments into specific genomic locations. This approach seeks to enhance the efficiency and precision of genetic modifications.
Gene therapies aim to cure genetic diseases by modifying the DNA blueprint.
An ideal gene therapy should be durable, safe, and efficient, which often requires integration of large therapeutic DNA cargo at precise genomic locations.
Advanced DNA editors with programmable specificities, such as the CRISPR technology, are limited by the nuclease-based mechanism and poor efficiency of large DNA insertions.
Increased efficiency, specificity and precision of large edits are required to address a broad…
KEMIJSKI INSTITUT
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