CORDIS Project
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This project investigates the molecular mechanisms behind the immune system's ability to recognize and eliminate infected or cancerous cells. It focuses on understanding the peptide-loading complex and the quality control processes of major histocompatibility complex class I molecules, which are crucial for effective i…
Our body constantly encounters pathogens or malignant transformation.
Consequently, the adaptive immune system is in place to eliminate infected or cancerous cells.
Specific immune reactions are triggered by selected peptide epitopes presented on major histocompatibility complex class I (MHC-I) molecules, which are scanned by cytotoxic T lymphocytes.Intracellular transport, loading, and editing of antigenic peptides onto MHC-I are coordinated by a highly dynamic multisubunit peptide-loading comp…
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
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