CORDIS Project
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This project aims to uncover the cellular and molecular mechanisms behind the development of multiciliated ependymal cells, which play a crucial role in cerebrospinal fluid flow and neurogenesis. It employs various advanced techniques to study their transformation from radial glial cells.
Understanding how billions of neurons are born, migrate and integrate into functional circuits has proved useful in elucidating the pathomechanisms of many neurodevelopmental disorders.
Multiciliated ependymal cells have attracted less interest and their development is still enigmatic.
However, their strategic location at the interface between brain ventricles and parenchyma and their unique morphology and functions strongly suggest that defects in the generation of these cells may be associated…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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