CORDIS Project
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The project investigates the cellular diversity of ependymal cells in the adult spinal cord using single-cell RNA sequencing. It aims to understand their self-renewal capabilities and lineage relationships, providing insights that could advance stem cell therapies for spinal cord injuries.
Cells with stem cell potential, this is with the ability to self-renew and generate specialised progeny, exist in the adult mammalian spinal cord.
Previous studies localised this potential within the ependymal cell (EC) population.
However, ECs are rather heterogeneous based on their morphological features and the expression of a handful of neural stem cell markers.
In this interdisciplinary research proposal, I aim to uncover the cellular and molecular heterogeneity of ECs at the level of indiv…
UNIVERSITY OF DUNDEE
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