CORDIS Project
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This project examines the structural properties of G- and C-rich DNA sequences, which can form unique quadruplex structures. The research aims to understand how environmental factors influence these structures, with implications for nanotechnology and biomedical applications.
Repetitive blocks of guanine- and cytosine-rich sequences, such as those occurring in centromeric and telomeric DNA regions and promoter regions of protein coding genes, have ability to form G- and C-quadruplex structures, respectively.
These non-B DNA structures are involved in more than 40 pathological human conditions including cancer.
From a biophysical point of view, a common property to both G- and C-rich sequences is their inherent sensitivity to non-specific, physical-chemical environmen…
Masarykova univerzita
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