CORDIS Project
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This project investigates the role of perineuronal nets (PNNs) and chondroitin sulphate proteoglycans (CSPGs) in enhancing memory and plasticity in the central nervous system. It aims to develop new treatments for memory loss associated with Alzheimer's disease and aging by manipulating PNNs to improve cognitive functi…
Inhibitory chondroitin sulphate proteoglycans (CSPGs) have several roles in CNS damage and repair, revealed by their digestion with chondroitinase.
Most recently, digestion of CSPGs in the limbic system and cortex has led to a very substantial enhancement of memory.The effects of CSPGs on plasticity and memory are largely through their concentration into PNNs, because transgenics lacking the PNN component link protein in the CNS have very attenuated PNNs, and show continuing plasticity into adul…
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