CORDIS Project
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This project investigates a novel approach to anti-tumor therapy by targeting the metabolic energy supply of blood vessels, rather than starving tumors. By mapping endothelial cell metabolism, the project aims to identify new anti-angiogenic candidates for cancer treatment through various experimental models.
Current anti-angiogenesis based anti-tumor therapy relies on starving tumors by blocking their vascular supply via inhibition of growth factors.
However, limitations such as resistance and toxicity, mandate conceptually distinct approaches.
We will explore an entirely novel and long-overlooked strategy to discover additional anti-angiogenic candidates, based on the following innovative concept: ¿rather than STARVING TUMORS BY BLOCKING THEIR VASCULAR SUPPLY, we intend TO STARVE BLOOD VESSELS BY B…
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