CORDIS Project
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The eCARB-X project introduces a sustainable electrochemical platform for transforming carboxylic acids into drug-relevant bioisosteres. This method avoids hazardous reagents and enhances the efficiency of drug discovery processes.
Carboxylic acids are among the most common functional groups in approved drugs, yet their polarity and metabolic instability often compromise pharmacokinetics and limit clinical translation.
Medicinal chemists routinely replace them with bioisosteres or extend their carbon chain, but existing methods rely on hazardous reagents, toxic intermediates, or unsustainable transition-metal catalysis.
The eCARB-X project pioneers a unified, metal-free electrochemical platform that expands Kolbe-type reac…
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Netherlands, Amsterdam
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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