CORDIS Project
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This project investigates how cancer cells utilize pyrimidine nucleotides from their environment, focusing on the role of endothelial cells in tumors. It aims to identify metabolic interactions and potential targets to enhance the effectiveness of pyrimidine synthesis inhibitors in cancer treatment.
It sounds simple:
A cell cannot divide without nucleotides.
Indeed, the disruption of pyrimidine de novo synthesis (PDNS) efficiently blocks proliferation of cancer cells.
Yet still today, PDNS-directed anticancer treatment has not entered clinics due to the lack of efficacy.
Why?
Cancer cells gain pyrimidines via PDNS or from salvage pathways, and PDNS inhibition in cancer cells can likely be bypassed by pyrimidines produced in the tumor environment or gained from the systemic circulation.
Can…
IBT INSTITUTE OF BIOTECHNOLOGY AS CRVVI
BIOTECHNOLOGICKY USTAV AV CR VVI
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