CORDIS Project
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This project investigates how immunoglobulins influence microbiota composition in early life and their role in developing allergies and asthma. It employs advanced techniques to analyze B cell receptor sequences and immunoglobulin functions, aiming to uncover the relationship between early immune exposures and long-ter…
Immunoglobulins (Igs) are thought to influence formation of the microbiota composition during a critical window of opportunity in early life.
Yet, the antigen binding profiles of these Igs are vastly unknown, and it is incompletely understood how early misguided immune education contributes to the development of allergies or asthma.
On an even more fundamental level, it is also unclear if or how B cell receptor (BCR) sequences of different individuals converge to binding similar microbiota antig…
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