CORDIS Project
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The project investigates how infections during early life affect the development of the intestinal lining and microbiota, which are crucial for long-term health. It employs advanced techniques to create a detailed map of epithelial cell differentiation and assess the impact of various pathogens on immune and metabolic…
Infections of the gastrointestinal tract and their long-term consequences remain a major cause of childhood mortality and morbidity worldwide.
In addition, early life is recognized as a critical and non-redundant time period to prime the mucosal tissue and establish the enteric microbiota that determine the risk to develop prevalent inflammatory, immune-mediated, and metabolic diseases.
Three factors: the enteric microbiota, the mucosal immune system and the epithelial barrier cooperate to estab…
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