CORDIS Project
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This project develops a novel approach using small molecules called 'molecular glues' to induce interactions between proteins, enabling targeted degradation of disease-related proteins that are difficult to drug. The focus is on applying this technology in cancer treatment, specifically ovarian carcinoma, through the r…
Conventional therapeutic strategy entails developing small molecules to occupy enzymatically active or regulatory pockets of the target protein, and further inhibit its biochemical activity.
However, many disease-relevant proteins, such as RAS, MYC, or b-catenin, lack manageable druggable cavities.
Bernardes and colleagues have raised a novel concept to overcome this limitation, named “molecular glues”, in which small molecules induce de-novo interactions between two proteins to modulate protei…
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
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