CORDIS Project
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This project investigates the roles of E3 ubiquitin ligases Arkadia and TIP11 in the TGF-beta signaling pathway, focusing on their potential as tumor suppressor genes in colon and pancreatic cancers. The research aims to identify genetic alterations and functional mechanisms of these ligases in cancer cell lines and tu…
The binding of TGF-b to its receptors induces phosphorylation of Smad2 and Smad3, their subsequent association to Smad4 and their nuclear translocation.
In the nucleus, the Smad3/Smad4 and Smad2/Smad4 heterodimers act as transcription factors and induce specific target genes. TGF-b pathway has a tumor suppressor function characterized by its ability to inhibit cell growth.
Many cancer cell lines have acquired resistance to the antiproliferative effect of TGF-b.
This is mainly achieved through lo…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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