CORDIS Project
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This project investigates the mechanisms by which E3 ubiquitin ligases selectively recognize their protein substrates in the ubiquitin-proteasome system. By employing functional genetic approaches, it aims to identify and characterize the specific degron motifs and pathways involved in protein degradation, enhancing ou…
As the primary route through which eukaryotic cells achieve selective protein degradation, the ubiquitin-proteasome system (UPS) plays a key role in virtually all critical cellular processes. A major unresolved question concerns how the ubiquitin system attains such high selectivity towards its myriad of substrates.
The main specificity determinants are the E3 ubiquitin ligases, which recognise cognate ‘degron’ motifs found in substrate proteins.
However, for the majority of the ~600 E3 ligases…
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