CORDIS Project
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This project investigates the regulation of type I interferons, which play a critical role in viral defense and inflammation. It aims to identify genetic factors that lead to excessive interferon activity, potentially informing new therapeutic strategies for related diseases.
Type I interferons represent both key molecules in anti-viral defence and mediators of inflammatory disease, so that the induction, transmission and resolution of the interferon response are tightly regulated - balancing protection against infection versus the risk of immunopathology.
Monogenic type I interferonopathies (T1IFNs), and related ‘complex’ phenotypes such as systemic lupus erythematosus and dermatomyositis, represent examples of a disturbance of the homeostatic control of this system…
THE UNIVERSITY OF EDINBURGH
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France, PARIS 15
Type: Research institute
Activity type: Research Organisations
SME: No
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