CORDIS Project
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This research investigates the role of extracellular matrix alterations in muscular dystrophies. By studying mouse models, the project aims to understand how these changes affect muscle cell behavior and identify potential therapeutic targets.
Most of the muscular dystrophies (MDs) are due to defects the trans-membrane protein complex called Dystro-GlycanComplex, which is a structural and functional bridge between myofiber contractile apparatus and extracellular matrix(ECM).MD
research is focused upon the cellular mechanisms of the pathology and there is a lack of information about howECM molecules can affect MDs, although alteration in ECM composition is acknowledged since fibrosis is an important badoutcome in
the patients.Our hypot…
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