CORDIS Project
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DynOMIS aims to uncover the mechanisms of antigen selection by major histocompatibility complex class I molecules, crucial for adaptive immunity. By integrating computational modeling and experimental methods, the project seeks to enhance vaccine development and immunotherapy strategies.
DynOMIS aims to elucidate the antigen selection mechanisms of the adaptive immune system at the molecular level in the highly complex cellular environment.
Major histocompatibility complex class I molecules (MHC-I) is a key mediator of adaptive immunity, the cell’s arsenal against infectious pathogens and malignant transformations. MHC-I present antigenic peptides to cytotoxic T lymphocytes at the cell surface, which in turn unleash their cytotoxic apparatus only when peptides from non-healthy p…
UNIVERSITY OF SOUTHAMPTON
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