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DYNOME is a platform designed to study gene expression dynamics at the single-molecule level. By utilizing advanced techniques, it aims to uncover the stochastic processes governing gene expression in bacteria and eukaryotic cells, with implications for drug development and understanding biological variability.
Gene expression is an inherently stochastic process.
Random expression bursts cause tremendous cell-to-cell variations in mRNA and protein levels.
The consequences are beneficial in some instances, e.g., in cell differentiation, and harmful in others, e.g., in bacterial drug tolerance. A key interest in biology is therefore to decipher the kinetics that characterise this noise.
What is the distribution of transcription rates in a cell population?
Are gene expression dynamics heritable?
Do gene n…
WEIZMANN INSTITUTE OF SCIENCE
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