CORDIS Project
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This project aims to develop a novel nanopillar array chip to study claudin proteins, which regulate tight junction permeability. The technology will facilitate the analysis of claudin channel activity, enhancing understanding of their role in health and disease.
Epithelial paracellular, i.e., tight junction, permeability is largely defined by the integrated functions of claudin proteins that can either seal the paracellular space or form highly-selective conductance channels.
The importance of claudins is exemplified by the many human diseases caused by barrier dysregulation and claudin mutations.
The host laboratory recently reported the first measurements of single channel tight junction currents, thereby demonstrating that claudin channels transition…
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
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United States, Boston
Type: Research institute
Activity type: Research Organisations
SME: No
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