CORDIS Project
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This project investigates how the arrangement of ligands at cell interfaces influences signaling in cells, focusing on Eph receptors and ephrins. By utilizing advanced techniques like DNA nanotechnology and super-resolution microscopy, it aims to understand the molecular mechanisms behind this spatial organization and…
There is mounting evidence that the spatial and temporal organization of ligands at cell-cell interfaces modulates signaling.
In particular, for Eph receptors and their ligands (ephrins) this phenomenon is widely recognized but poorly understood due to difficulties in controlling and analyzing membrane protein microenvironments at the nanoscale. A combination of different techniques ranging from DNA nanotechnology to high resolution microscopies via standard biochemical techniques and computatio…
KAROLINSKA INSTITUTET
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