CORDIS Project
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This project investigates the spatial and temporal factors influencing tumor progression in Acute Myeloid Leukemia (AML). By developing mouse models, it aims to understand how aging and spatial dynamics contribute to cancer development and identify potential therapeutic targets.
Advances in sequencing-based phylogenetic studies applied to cancer evolution have led to the observation that the linear accumulation of oncogenic alterations over individuals lifespan does not match the late life pattern of cancer incidence.
It has thus become clear that beyond the sequential accumulation of oncogenic driver mutations, additional factors also support cancer outgrowth.
The temporal and spatial dynamics of tumor evolution represent two of the most critical mutation-independent v…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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