CORDIS Project
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This project investigates how neurons adapt by identifying localized mRNAs and proteins at synapses. Using advanced sequencing and imaging techniques, it aims to understand the role of local protein synthesis in synaptic plasticity and how environmental changes influence neuronal function.
The ability of the nervous system to respond adaptively relies on modifications to existing proteins as well as changes in gene transcription and protein translation.
An individual neuron in the brain possesses approximately 10.000 synapses, many of which are hundreds of microns away from the cell body.
As many of the changes to environmental stimuli occur at synapses, the question arises as to how the modified synapses gain access to the new mRNAs and proteins.
It is now clear that synapses pos…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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