CORDIS Project
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This project investigates the mechanisms behind drug resistance in colorectal cancer, focusing on genetic and epigenetic changes in cancer cells. By utilizing patient-derived models and advanced computational methods, it aims to identify new strategies to combat treatment resistance and improve patient outcomes.
Tumours evolve, transforming from early-stage curable disease into treatment-refractory, deadly cancer.
Therapy resistance is arguably the biggest problem in oncology today, and much of it remains unexplained.
The central hypothesis of this proposal is that a large proportion of unexplained drug resistance is due to heritable epigenetic alterations, and non-heritable transcriptional plasticity in cancer cells. I refer to these mechanisms as the dark matter of cancer evolution.
Genetic, epigeneti…
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