CORDIS Project
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This project investigates the molecular mechanisms of cellular reprogramming during mouse development, focusing on the dynamics of DNA and RNA modifications. By analyzing totipotent cells and primordial germ cells, it aims to uncover the epigenetic changes that occur as cells differentiate.
Development of any organism starts with a totipotent cell (zygote).
Through series of cell divisions and differentiation processes this cell will eventually give rise to the whole organism containing hundreds of specialised cell.
While the cells at the onset of development have the capacity to generate all cell types (ie are toti-or pluripotent), this developmental capacity is progressively lost as the cells undertake cell fate decisions.
At the molecular level, the memory of these events is lai…
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