CORDIS Project
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This research investigates the molecular interactions of paramyxoviruses, focusing on the nucleoprotein and phosphoprotein involved in viral replication. The project aims to understand their conformational dynamics and the formation of liquid-like droplets, which could reveal new insights into viral biology.
Paramyxoviruses, including, measles and a number of dangerous human pathogens, are negative strand RNA viruses that express their own machinery for transcription and replication.
Different interactions between the nucleoprotein (N) and the phosphoprotein (P) are essential for chaperoning and assembly of N on newly synthesized RNA genomes to form nucleocapsids (NCs), as well as for initiating replication and transcription.
Both N and tetrameric P exhibit extensive conformational disorder, with ve…
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