CORDIS Project
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This research focuses on developmentally regulated genome rearrangements in eukaryotes, particularly in the ciliate Paramecium. It aims to study the evolutionary significance and mechanisms of genome reorganization, contributing to our understanding of genetic diversity and cellular fate.
Genomes are highly dynamic units that often undergo events of reorganization which are formally called developmentally regulated genome rearrangements (DRGRs). DRGRs, like for example chromatin/chromosome elimination or chromatin diminution are widespread throughout eukaryotes (e.g., ciliates, animals, insects, kinetoplastids, foraminifera, entamoebae) and create diversity in genome architecture, often producing significant changes in the fate of the affected cells.
The relevance and the consequ…
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