CORDIS Project
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This project introduces dynamic combinatorial chemistry to study molecular recognition at bilayer membranes. It aims to create synthetic receptors and investigate the action of gramicidin antibiotics at the lipid bilayer interface.
Molecular recognition at bilayer membranes is key to many vital processes in biology, yet notoriously difficult to study.
Aim of this project is to introduce a new technique to this field: dynamic combinatorial chemistry.
We propose to adapt reversible thioester chemistry to this end and use it for two different purposes:(i) Discovering new synthetic receptors that are optimized for operating at the bilayer interface.
This should lead to new fundamental insights into what differentiates molecula…
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