CORDIS Project
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This project aims to enhance the understanding of nicotinic acetylcholine receptors, which are crucial for neuronal communication. By studying their conformational changes and interactions with lipids and drugs, it seeks to inform the development of new therapeutic strategies.
Nicotinic acetylcholine receptors (nAChRs) mediate neuronal synaptic transmission and modulation.
They contribute to higher brain functions such as cognition and reward and are important drug targets.
Recent studies have revealed that these acetylcholine-gated ion channels display an unanticipated conformational plasticity, adopting multiple allosteric states that shape the time course of their electrophysiological response.
To date, a single nAChR structure has been solved at high resolution, a…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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