CORDIS Project
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This project investigates the dual spindle assembly in mammalian zygotes, focusing on the mechanisms behind spindle formation and alignment during the first cell division. By utilizing advanced microscopy techniques, it aims to enhance understanding of cell division errors that may contribute to human infertility.
The first embryonic division after fertilization is essential for development of the organism and has to promote the union of the parental genomes.
My host lab recently showed that in mammalian zygotes two bipolar spindles form, which first independently congress the maternal and paternal chromosomes and then must be aligned in parallel for a faithful division.
The novel dual spindle assembly provided a likely rationale for erroneous divisions into more than two blastomeric nuclei observed in hu…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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