CORDIS Project
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This study investigates the relationship between inflammation and intestinal tumors by analyzing how specific oncogenes influence the immune environment. It aims to uncover mechanisms that could lead to new personalized therapies for cancer treatment.
An association between inflammation and carcinogenesis is well established, however, how they are related mechanistically in subtypes of sporadic intestinal tumours remains unclear.
This study aims to decipher how oncogenes determine the inflammatory microenvironment (stroma) and how this affects tumour development and survival.
Notably, intestinal epithelium-specific expression of oncogenic Kras(G12D), Braf(V637E) and Pik3ca(H1047R) in mice mimics serrated intestinal cancers in humans faithfull…
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
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