CORDIS Project
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This project investigates the molecular mechanisms behind DNA break formation during meiosis, which is crucial for fertility. By studying these processes in mice, it aims to understand how to maintain genome integrity during this critical phase of cell division.
At the onset of prophase of the first meiotic division, meiotic cells undergo complex molecular events with the induction of several hundred DNA double-strand breaks.
These DNA breaks are required because they initiate recombination between homologous chromosomes and to allow chromosome segregation during meiosis.
They are essential for fertility.
However, they represent a major challenge for genome integrity.It is thought that meiotic DNA break formation is under tight control to ensure that al…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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