CORDIS Project
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This project aims to develop targeted therapies for inherited retinal degenerations by focusing on the regulation of cyclic guanosine monophosphate (cGMP). The goal is to prevent photoreceptor damage and improve treatment options for patients with retinal diseases.
Dysregulation of cGMP is a pathological hallmark of inherited retinal degenerations (RD) affecting photoreceptors, the sensory cells of the retina.
These RDs, including Retinitis Pigmentosa, Lebers Congenital Amaurosis, and Achromatopsia, are major causes of blindness, affecting approximately one in every 2000 individuals worldwide, and remain without effective treatment.
In photoreceptors, cGMP is produced by retinal guanylyl cyclase (GC).
The two main cGMP targets are cyclic nucleotide gated i…
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Netherlands, LEIDEN
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
Germany, BREMEN
Type: SME
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: Yes
Italy, Modena
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Sweden, LUND
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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