CORDIS Project
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This project focuses on developing chemical tools to study how multiprotein complexes recognize and interact with each other. By investigating Cullin RING Ligases, the project aims to identify new druggable surfaces for potential therapeutic targets in various diseases.
This proposal is centred on the development and application of chemical tools to probe molecular recognition of multiprotein complexes.
Although much effort has been devoted to targeting protein-protein interactions using small molecules, these have focused to date on individual gene products or truncated domains, which however do not reflect the physiological organization and activity of many functional proteins.
Few successes have been achieved, yet many of the key physical determinants of dru…
UNIVERSITY OF DUNDEE
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