CORDIS Project
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This project utilizes the Drosophila model to identify new genes involved in iron regulation in multicellular organisms. By employing genetic screens, it aims to uncover factors affecting iron homeostasis that are relevant to human health.
The Drosophila model will be used for two complementary and unbiased genetic screens, designed to identify novel genes that affect iron homeostasis in multi-cellular organisms. S. cerevisiae has been used successfully for the same purpose, however this unicellular organism does not express neither ferritin (the major iron storage protein) nor iron regulatory proteins (the major regulators of intracellular iron homeostasis in mammals).
Knockout mouse models of known iron metabolism genes have bee…
QUEEN MARY UNIVERSITY OF LONDON
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