CORDIS Project
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This research investigates the impact of mutations in genes linked to Parkinson's disease using fruit fly models. The study aims to understand how these mutations affect mitochondrial function and oxidative stress, potentially leading to new therapeutic strategies.
Mutations in human genes parkin and DJ-1 cause susceptibility to Parkinson's disease (PD).
Both genes have functions linking them to mitochondria and oxidative stress.
Parkin protein is a ubiqutin E3 ligase which targets damaged proteins for proteasomal degradation and it has also been shown to localize to dysfunctional mitochondria.
Protein DJ-1 has functions as a ROS scavenger and a gene expression regulator of other stress genes.
My research uses Drosophila melanogaster lines with mutations i…
TAMPEREEN YLIOPISTO
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