CORDIS Project
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This project develops a human-specific platform using directly reprogrammed renal epithelial cells to screen for nephrotoxicity in drugs. It aims to provide a scalable, high-throughput alternative to traditional animal testing, enhancing drug safety and reducing late-stage failures.
Acute tubular necrosis (ATN) is a major cause of nephrotoxicity-related drug attrition in clinical trials, yet current preclinical models rely on animal studies or immortalized renal cell lines, which lack human physiological relevance.
To address this gap, we have developed a directly reprogrammed renal epithelial cell (iREC) platform, enabling a human-specific, scalable, and high-throughput nephrotoxicity screening assay.Our iREC-based system overcomes the limitations of primary, or iPSC-deriv…
UNIVERSITAT ZURICH
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