CORDIS Project
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This project investigates how genetically identical bacterial cells exhibit different behaviors due to fluctuations in DNA repair proteins, specifically RecBCD in Escherichia coli and AddAB in Bacillus subtilis. By analyzing these fluctuations and their effects on cell survival, the research aims to enhance understandi…
Cells growing in identical environments can display substantial phenotypic heterogeneity within a population.
This is partly due to changes in genetic information that in turn cause systematic changes in expression rates.
It has also recently been shown that even genetically identical cells behave differently because many cellular processes involve molecules present in small numbers which causes significant cell-to-cell fluctuations.
Genetic and non-genetic sources of heterogeneity may be connec…
THE UNIVERSITY OF EDINBURGH
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