CORDIS Project
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This project focuses on designing small molecule mimetics to disrupt protein-protein interactions that regulate cell death. By targeting specific amino acid residues, it aims to develop new therapeutic strategies for diseases like cancer through innovative synthetic chemistry.
Many critical processes within cells, including those that control whether a cell lives and divides or dies, are mediated by protein–protein interactions (PPIs).
In certain disease states, such as cancer, these interactions can become defective in a way where disruption of the interaction has therapeutic benefit.
Replacement of one of the protein partners, which often have α-helical secondary structure, with a small molecule is one method of disruption; however, the interface can often be large…
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