CORDIS Project
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The project aims to discover inhibitors for the gankyrin-S6 protein complex, which is implicated in certain cancers. By employing a diversity-oriented synthesis approach, the research seeks to develop new compounds that can modulate protein interactions, potentially leading to novel treatments for these diseases.
(1) GoalThe project goal is to exploit diversity-oriented synthesis (DOS) to discover protein-protein interaction (PPI) inhibitors of gankyrin-S6 complex.(2) TopicVital cellular functions are all regulated by protein complexes.
In order for a complex to work correctly, interactions among its subunits must have the right intensity.
If they are too weak or too strong, the complex does not work well, causing disease.
Thus, modulation of PPIs offers a strategy for therapy.
Gankyrin is a protein th…
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