CORDIS Project
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DORMATRIX aims to understand and engineer the transition of breast cancer from dormancy to active growth using biomaterials-based devices. By modeling cancer micro-units and applying biophysical principles, the project seeks to develop new therapies that can delay or prevent metastasis.
Cancer dormancy and the trigger to transition to active metastatic growth is a big open question.
Current in vivo models focus on niche-specific cell and molecular mechanisms, ignoring biophysical aspects.
Dormancy evolves with complex spatio-temporal dynamics; yet, there is a knowledge gap in the understanding of the heterogeneity of the units, and the dynamics of their interaction and evolution.
Emergence occurs when a critical mass of units synergistically communicates giving rise to a new ma…
ASOCIACION INSTITUTO BIOGIPUZKOA
ASOCIACION INSTITUTO DE INVESTIGACION SANITARIA BIOGIPUZKOA
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