CORDIS Project
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This project investigates how dopamine signaling in the brain's master clock affects energy metabolism and cardiovascular health. It aims to understand the impact of disrupted daily rhythms on metabolic diseases, particularly in the context of obesity.
The internal daily rhythms of an organism are driven by the circadian timing system.
The master clock is in the brain hypothalamic suprachiasmatic nuclei (SCN). SCN rhythms are entrained to the 24h environmental light/dark cycle by retinal light input, but also respond to non-photic cues (e.g., food intake) transmitted via neuronal projections from other brain areas.
Disruption of daily rhythms can lead to cardiometabolic diseases, but the underlying mechanisms are unclear.
Recent evidence chall…
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