CORDIS Project
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DOPA-Kiss investigates how early obesity affects puberty by focusing on specific brain neurons involved in metabolic regulation. The project aims to uncover the mechanisms linking obesity to pubertal changes, providing insights into potential interventions for obesity-related health issues.
Child obesity is a worrying condition, affecting 20% adolescents.
Among its comorbidities, early obesity is linked to disturbed puberty, which is more evident in girls, but bound to adverse health outcomes in both sexes.
Yet, how our brain decodes nutritional info to finely control puberty remains unsolved.
Genetic data suggest obesity is largely an hypothalamic disease.
Puberty is also hypothalamic-driven and governed by complex neuronal circuits.
Among them, Kiss1 neurons have emerged as key e…
UNIVERSIDAD DE CORDOBA
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