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The DOMDICAS project aims to develop a new method for synthesizing complex natural compounds called Strychnos alkaloids using a combination of organocatalysts and metal catalysts. This innovative approach will enhance the efficiency and control in creating new chemical bonds, facilitating the production of bioactive ma…
The combination of an organocatalyst and a metal catalyst in a single transformation provides novel reactivity and high control in the creation of new bonds.
However, this approach has never been applied to the synthesis of complex natural alkaloids.
The aim of DOMDICAS is the development of a novel dual-catalysed asymmetric desymmetrisation methodology and its application to the synthesis of Strychnos alkaloids leuconicines A and B.
In the first stage of the proposed research, a dual catalytic…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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